Applying UHPLC-HRAM MS technology to characterize and quantify lipid components in vivo to support new LNP development

Application note | 000464 Mass Spectrometry Characterization and quantification of lipid nanoparticle components and their impurities/degradants using an LC-HRAM MS platform Authors Application benefits Reiko Kiyonami , Ralf Tautenhahn , 1 1 • Confident lipid nanoparticle (LNP) component confirmation through…

Characterization and quantification of lipid nanoparticle components and their degradants in vivo using an LC-HRAM MS platform Reiko Kiyonami1, Ralf Tautenhahn1, Min Du2, Sinae Lee3, Evgenia Verovskaya3, Jason Potter3, 1Thermo Fisher Scientific, San Jose, CA; 2Thermo Fisher Scientific, Cambridge, MA,…

Biopharmaceuticals Analytical solutions for mRNA vaccines and therapeutics Table of contents mRNA vaccines and therapeutics mRNA characterization Lipid nanoparticle characterization Critical quality attributes of mRNA therapeutics Direct mRNA sequence confirmation LNP composition analysis by LC-CAD Optimize impurity analysis with ease…

Application Note Rapid Analysis of Lipid Nanoparticle Components Using BioAccord LC-MS System Giorgis Isaac, Nilini Ranbaduge, Bonnie A. Alden, Colette Quinn, Weibin Chen, Robert S. Plumb Waters Corporation Abstract The recent success of mRNA vaccines for COVID-19 is in part…