Imaging Lipids in a Brain Injury Model with AP‑MALDI on the Agilent 6495 Triple Quadrupole and 6560 Ion Mobility Mass Spectrometers

[ APPLICATION NOTEBOOK ] MS IMAGING AND AMBIENT IONIZATION-MS FOR METABOLOMICS AND LIPIDOMICS 1 This notebook is an excerpt from the larger Waters’ Application Notebook on Metabolomics and Lipidomics #720005245EN TABLE OF CONTENTS 3 Introduction 4 Biomarker Discovery Directly from…

COLLISION CROSS SECTION ENABLED DESI ION MOBILITY MASS SPECTROMETRY IMAGING Anthony J. Midey, Hernando J. Olivos, and Bindesh Shrestha Waters Corp., Beverly, MA INTRODUCTION Mass spectrometry imaging (MSI) determines the localization of compounds on samples, including tissue sections and drug…

Intensity (arb. unit) 132% 0% 100% PS 38:1 m/z 816.5747 ± 0.0122 1/K0 1.433 ± 0.01 Intensity (arb. unit) Mobility [1/K0] 136% 0% 100% PE 20:1_22:6 m/z 816.5517 ± 0.0122 1/K0 1.404 ± 0.01 m/z 1 mm CCS-aware SpatialOMx® enables…

Application Note Using Targeted MRM MS Imaging With DESI to Visually Localize Isobaric And/or Low Abundance Lipids Emmanuelle Claude Waters Corporation Abstract DESI technique ionizes small molecules such as lipids, efficiently directly from surfaces such as tissue sections, without any…