Semi-preparative reversed-phase liquid chromatographic purification of oligonucleotides

LC purification Semi-preparative reversed-phase liquid chromatographic purification of oligonucleotides Dennis Köhler1, Anna Spanopoulou2, Susanne Fabel1, Robert Galik2, Thomas Halbritter2, Mandy Deimel2 1Thermo Fisher Scientific, Germering, Germany 2Eurofins Genomics Europe Pharma and Diagnostic Products & Services Synthesis GmbH, Ebersberg, Germany Abstract…

Application note | 003192 Biopharma Case study: Instrument and LC column migration for the purification and analysis of synthetic oligonucleotides Authors Application benefits Dennis Köhler1, Talia Hill2, Susanne Fabel1 • A workflow migration of semi-preparative reversed-phase chromatographic purification and subsequent…

Application note | 003192 Biopharma Method transfer case study for instrument and LC column migration of the purification and analysis workflow for synthetic oligonucleotides Authors Application benefits Dennis Köhler1, Talia Hill2, Susanne Fabel1 • A method transfer of semi-preparative purification…

Ensuring precise isolation of macromolecules by hyphenating UHPLC separation power with exact fractionation for analytical and semi-preparative LC purification Sabrina Patzelt, Dennis Köhler, and Susanne Fabel Thermo Fisher Scientific, Dornierstrasse 4. 82110 Germering, Germany l Introduction The technique of fraction…