Characterization of Small Immunoconjugates (< 40 kDa) Using Capillary Electrophoresis–Mass Spectrometry

Application Note Biopharma Analysis of Antibody Fragment-Drug Conjugates Using an Agilent AdvanceBio SEC 120 Å 1.9 µm PEEK-Lined Column Monoclonal antibody Authors Benjamin Stenton Antikor Andrew Coffey and Veronica Qin Agilent Technologies, Inc. Single-chain Fv (scFv) Abstract Antibody drug conjugates…

Characterization of Monoclonal Antibodies Using Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry (CE-ESI-MS) Application Note Authors Abstract Suresh Babu CV and Ravindra Gudihal This Application Note demonstrates the utility of capillary electrophoresis/mass Agilent Technologies Pvt Ltd spectrometry (CE/MS) for the analysis of intact…

Agilent BioHPLC columns Characterization of Antibody-Drug Conjugate Critical Quality Attributes Application compendium Contents Introduction3 Featured application notes 2 PLRP-S Polymeric Reversed-Phase Column for LC/MS Separation of mAbs and ADC (5991-7163EN) 5 Intact- and Peptide-Level Characterization of Trastuzumab Emtansine In Vitro…

Application Note Biopharma Comprehensive Approaches to Higher-Order Structure of Intact Proteins by Native Mass Spectrometry Authors Caroline S. Chu, Patrick D. Perkins, Christian Klein, and Andrew Gieschen Agilent Technologies, Inc. Abstract This application note presents different approaches to native mass…