PHARMSCI: Rapid Analysis and Characterization of Lipid Nanoparticle Components for mRNA Delivery

Rapid Analysis of Lipid Nanoparticle Components Using BioAccord™ LC-MS System Giorgis Isaac, Nilini Ranbaduge, Colette Quinn, Weibin Chen and Robert S. Plumb Waters Corporation, Milford, MA Introduction ▪ The recent success of mRNA vaccines in SARSCoV-2 clinical trials is in…

Application Note Rapid Analysis of Lipid Nanoparticle Components Using BioAccord LC-MS System Giorgis Isaac, Nilini Ranbaduge, Bonnie A. Alden, Colette Quinn, Weibin Chen, Robert S. Plumb Waters Corporation Abstract The recent success of mRNA vaccines for COVID-19 is in part…

LIPID NANOPARTICLES—GET TO KNOW THEM ANALYTICALLY Giorgis Isaac; Nilini Ranbaduge; Bonnie Alden; Colette Quinn; Weibin Chen Waters Corporation, Milford, MA 01757 INTRODUCTION Lipid Nanoparticles (LNPs) The recent success of mRNA vaccines is largely due to their ability to use human…

Application Note Characterizing and Monitoring Impurities in Lipid Nanoparticle Components Using the BioAccord™ LC-MS System with waters_connect™ Software Kellen DeLaney, Duanduan Han, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Lipid nanoparticles (LNP) have been used with high efficacy…