Novel ion activation workflows in the hybrid Orbitrap-Omnitrap platform empower top-down and bottom-up proteomics

AS MS 2 0 2 5 – M P 4 7 1 Advances in hardware design and function of the new timsOmni MS platform D. Papanastasiou1; A. Smyrnakis1; M. Kosmopoulou1; A. Grigoriadis1; I. Orfanopoulos1; N. Manolis1; I. Panagiotopoulos1; R. Gioves1;…

Top-down Analysis of Intact Antibodies under Denatured and Native Conditions on the Omnitrap Platform Coupled to an Orbitrap Mass Spectrometer Mariangela Mariangela Kosmopoulou1; Athanasios Smyrnakis1, Dimitris Papanastasiou1; Kyle L Fort2, Alexander Makarov2, Roman Zubarev3 1Fasmatech, Lefkippos Tech Park, NCSR Demokritos,…

AS MS 2 0 2 5 – M P 7 1 3 n Offline tandem MS workflows on the timsOmni platform for deep sequencing of intact proteins and mAbs Athanasios Smyrnakis1, Mariangela Kosmopoulou1, Anastasios Grigoriadis1, Florian Busch2, Stuart Pengelley3, Eduardo…

T HP 645 ASM S 2026 Location, Location, Location… Native Top-Down Mass Spectrometry Provides Binding Site Information for Protein-Ligand and ProteinProtein Interactions Results and Discussion  High density electron beam from hot cathode 1Fasmatech Science & Technology, Chalandri, Greece; 2Bruker…