Experimental and Computational Comparison of Collision Cell and In-Source Collisionally Activated Dissociation Kinetics in an IM-QTOF Instrument

ExD AQ-25x Option AQ-251 • AQ-252 for Agilent LC/Q-TOF User Guide R011 • November 2023 Notices Notices About this Guide Patents The purpose of this document is to provide: This product is protected by U.S. patents 8,723,113 B2; 9,269,556 B2;…

Origins and Mitigation of Unwanted Dissociation of Fragile Analyte Ions in Compact Quadrupole Orbitrap Mass Spectrometers Erik P.A. Couzijn†; Siegrun A.I. Mohring†; Ioanna Ntai‡; Jan-Peter Hauschild†; Alexander Harder†; Alexander A. Makarov† †Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany; ‡Thermo Fisher…

Application Note Biopharma Top-Down Sequence Analysis of Intact Proteins Using an Agilent AdvanceBio 6545XT LC/Q-TOF with ExD Authors Rachel Franklin and Mike Hare Agilent Technologies, Inc. Abstract Detailed proteoform characterization is crucial for understanding disease mode of action (MOA) and…

Mass spectrometer interface visualisation techniques in atmospheric pressure and vacuum sections Roch Andrzejewski1; Andrew Entwistle1; Jeff Chadbourne1; Philip Albericci1; Benjamin Brown1,2; Patrick Knight1 1Shimadzu Research Laboratory (Europe), Manchester, United Kingdom; 2 Department of Chemistry, University of York, York, United Kingdom…