Analysis of siRNA Drugs at Denaturing UPLC Conditions Using MaxPeak Premier Column Technology

Application Note Analysis of siRNA Duplexes at NonDenaturing UPLC Conditions Using MaxPeak Premier Column Technology Pratheeba Yogendrarajah, Willy Verluyten, Evelien Dejaegere, Leslie Napoletano, Jean-Paul Boon, Mario Hellings , Martin Gilar Analytical Development, Janssen Pharmaceutical Companies of Johnson & Johnson, Waters…

Application Note Reproducible Hydrophilic Interaction Chromatography for Denaturing and NonDenaturing Analyses of Oligonucleotides Using GTxResolve Premier BEH Amide Columns Abraham S. Finny, Tatiana Johnston, Brent Sauner, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation For research use only. Not for use…

Application Note Improved Chromatographic Analysis of Oligonucleotides with ACQUITY PREMIER Oligonucleotide BEH C18 Columns Martin Gilar, Zhimin Li, Jason MacLean Waters Corporation Abstract This application note illustrates sources of oligonucleotide loss due to adsorption on metallic column hardware (frits). Solutions,…

Improving Chromatographic Separations Of Biopharmaceuticals With MaxPeak High Performance Surfaces (HPS) Technology Analytical Solutions Using MaxPeak High Performance Surfaces (HPS) Technology for Biopharmaceutical Therapeutics Biopharmaceutical therapeutics have consistently been the fastest growing segment within the pharmaceutical space and require advances…