A COMBINED WORKFLOW FOR IN-DEPTH CHARACTERIZATION OF CYSTEINE-CONJUGATED ANTIBODY DRUG CONJUGATES

A COMBINED WORKFLOW FOR IN-DEPTH CHARACTERIZATION OF CYSTEINE-CONJUGATED ANTIBODY DRUG CONJUGATES Liuxi Chen1, Robert Birdsall1, Henry Shion1, Ying Qing Yu1, Frank W. Kotch2, April Xu3, Thomas J. Porter4, Weibin Chen1 1 Waters Corporation, Milford, MA; 2Pfizer Bioprocess Research & Development,…

Development of Integrated Informatics Workflows for the Automated Assessment of Comparability for Antibody Drug Conjugates (ADCs) Using LC-UV and LC-UV/MS Henry Shion, Robert Birdsall, Steve Cubbedge, and Weibin Chen Waters Corporation, Milford, MA, USA A P P L I C…

[ APPLICATION NOTE ] Analytical Scale Native SEC-MS for Antibody-Drug Conjugates (ADCs) Characterization Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ An improved native mass spectrometry with analytical scale Size…

BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…