Analysis of Cysteine-Conjugated Antibody Drug Conjugates (ADCs) Using a Native SEC LC-MS Workflow on the SYNAPT XS

[ TECHNOLOGY BRIEF ] Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA Drug-to-Antibody Ratio (DAR) determination of Lys and Cys conjugated…

[ APPLICATION NOTE ] Analytical Scale Native SEC-MS for Antibody-Drug Conjugates (ADCs) Characterization Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ An improved native mass spectrometry with analytical scale Size…

Development of Integrated Informatics Workflows for the Automated Assessment of Comparability for Antibody Drug Conjugates (ADCs) Using LC-UV and LC-UV/MS Henry Shion, Robert Birdsall, Steve Cubbedge, and Weibin Chen Waters Corporation, Milford, MA, USA A P P L I C…

Application Note Advancing ADC Characterization: SECBased Native DAR and Drug Distribution Analysis Using Multi-Reflecting TOF-MS and INTACT Mass Application Jonathan Fox, Scott J Berger, Laetitia Denbigh, Sam Ippoliti Waters Corporation, United States Published on December 24, 2025 Abstract This technology…